The physicians at SleepScriptMD have over 30 years of combined experience helping patients achieve better sleep. At SleepScriptMD.com, we use both synchronous and AI-assisted asynchronous treatments to manage sleep disorders, providing safe, non-addictive medication and supplement options.
This guide is for informational purposes only and not a substitute for medical advice. Any treatment—whether a supplement, medication, procedure, injection, therapy, or device—carries potential risks, especially when used in excess or by individuals with certain medical conditions or genetic predispositions. Always consult a qualified healthcare provider before starting any treatment.
Understanding Mirtazapine
Mirtazapine (Remeron) is primarily an antidepressant used for treating major depressive disorder (MDD). It functions by increasing levels of neurotransmitters like norepinephrine and serotonin, which are crucial for regulating mood and sleep. While its primary use is for depression, it is also prescribed off-label for insomnia due to its sedative effects.
How Mirtazapine Works
Mirtazapine is classified as a tetracyclic antidepressant. Unlike SSRIs, it enhances norepinephrine and serotonin activity differently, leading to improvements in mood, sleep, and appetite regulation.
Mirtazapine for Insomnia
Though not FDA-approved specifically for insomnia, Mirtazapine is frequently used off-label to promote sleep. Research suggests that it can help with:
- Falling asleep faster
- Reducing nighttime awakenings
- Improving overall sleep quality
It is particularly effective for individuals experiencing both depression and sleep disturbances. Some studies indicate benefits even for those without depression who struggle with chronic insomnia.
Dosage for Sleep Disorders
For insomnia, low doses of Mirtazapine (7.5 to 15 mg at bedtime) are often effective. These doses maximize its sedative effects while reducing the risk of unwanted side effects. Higher doses (>30 mg) tend to have less sedative impact and may not be as beneficial for sleep.
Common Side Effects
While Mirtazapine is generally well-tolerated, it does have some potential side effects, including:
- Drowsiness (which can be beneficial for insomnia)
- Increased appetite & weight gain
- Dry mouth
- Occasional vivid dreams or nightmares
Serious but less common side effects may include serotonin syndrome, mood changes, or withdrawal symptoms upon abrupt discontinuation. It should be used cautiously in individuals with heart conditions, seizure disorders, or bipolar disorder.
Accessing Insomnia Treatment at SleepScriptMD
At SleepScriptMD.com, we specialize in treating insomnia with safe, non-addictive options. Our approach includes:
- Synchronous (live) and AI-assisted asynchronous care for maximum flexibility
- Multiple prescription & supplement options tailored to individual needs
- Access to at-home sleep tests to identify underlying sleep disorders
- Cognitive Behavioral Therapy for Insomnia (CBT-i) with expert sleep coaches
If you’re struggling with insomnia, SleepScriptMD.com can help you find an effective, personalized treatment plan. Visit our website to learn more about how we can improve your sleep today!
Sources
- Sleepstation: “Mirtazapine and Sleep: Will it Help You Sleep Better?” https://www.sleepstation.org.uk/articles/medicines/mirtazapine/
- Sleep Foundation: “Does Mirtazapine Help You Sleep?” https://www.sleepfoundation.org/sleep-aids/mirtazapine-for-sleep
- K Health: “Mirtazapine For Sleep: What You Need to Know” https://khealth.com/learn/antidepressants/mirtazapine-for-sleep/
- NCBI: “Effective Treatment of Insomnia With Mirtazapine Attenuates Concomitant Suicidal Ideation” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940447/
- Dawn Health: “Mirtazapine for Sleep” https://www.dawn.health/blog/mirtazapine-for-sleep
